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Clinical trials

A ‘clinical trial’ is a research study in which people agree to test a potential new treatment to prevent or improve a disease or medical condition. A clinical trial also looks at how participants react to the potential new treatment and if any unwanted effects occur. This helps to determine if the new investigational treatment works, is safe, and is better than those that are already available. Many clinical trials also compare existing treatments or test new ways to use or combine existing treatments.

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The FUZE Clinical Trial of Debio 1347 in advanced solid tumors harboring a FGFR fusion

The FUZE Clinical Trial is evaluating an oral investigational medicinal product, called Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic.Discover more .
The FGFR genes Definition a gene is like a blueprint defining what a cell should look like (placed in the DNA) provide instructions for making proteins called fibroblast growth factor receptors (FGFRs). These proteins play a role in important cellular processes. The presence of a specific alteration of the FGFR genes Definition a gene is like a blueprint defining what a cell should look like – called a fusion – induces the presence of altered receptors and may be associated with tumor cells growth. Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic.Discover more is specifically targeted against these altered receptors.
The FUZE trial is a Phase II trial in adult male and female patients with advanced or metastatic tumors whose cells show specific FGFR gene alterations, namely FGFR1, FGFR2 or FGFR3 gene fusions. To be eligible, patients must require therapy and have radiologic and/or clinical progression following at least one prior standard treatment or have no satisfactory alternative treatment options. In this trial, biliary tract cancer (such as cholangiocarcinoma), urothelial cancer (such as bladder cancer) and other solid tumors (such as lung cancer, head and neck cancer, breast cancer, endometrial cancer, colon cancer and others) are being studied. Patients with primary brain tumors cannot enter this trial.
The purpose of the trial is to assess whether Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic.Discover more is able to target and inhibit these altered FGFR genes Definition a gene is like a blueprint defining what a cell should look like and thereby facilitate cancer cell death and shrinkage of the tumor.
Patients will be recruited in North America, Europe, South America and the Asia Pacific region.

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Talk with your medical doctor

If you are interested in participating in an upcoming clinical trial, ask your doctor if a clinical trial might be right for you. Your doctor knows both you and your health history, which is invaluable in making this decision. Your doctor can help you gather the information needed to locate a trial and help you identify what questions might be important to ask before deciding to participate. When you join a clinical trial, you will still receive care from your primary doctor for your overall health. Most trials are only for a limited time and only pertain to the condition being studied.d.

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Find the trials on the map

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Clinical trial of Debio 1347 in advanced solid tumor malignancies

Debiopharm International is conducting the second part of a Phase I trial in male and female patients with advanced solid tumor malignancies, whose tumor cells show an alteration of specific genes Definition a gene is like a blueprint defining what a cell should look like (FGFR1, 2 or 3 genes Definition a gene is like a blueprint defining what a cell should look like ) and for whom standard treatment does not exist or is not indicated.

The presence of altered genes Definition a gene is like a blueprint defining what a cell should look like in these solid tumors may help the tumor cells to grow via receptors called fibroblast growth factor receptors 1, 2 and 3 on their surface. Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic. More info: http://bit.ly/2xHPMKb , the investigational medicinal product that is tested in this trial, is specifically targeted against these receptors. The purpose of second part of the trial is to confirm the safety profile at the proposed Recommended Dose.

The patients are treated with Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic. More info: http://bit.ly/2xHPMKb oral tablets daily in 28-day cycles until disease progression or until treatment discontinuation is required for other reasons.

In a first part of this trial, the highest dose of Debio 1347 Definition Debio 1347 is an orally available small molecule targeting FGFR 1, 2, 3 signaling pathways . Debio 1347 is currently in phase I for the treatment of advanced solid tumors. It already showed anti-cancer efficacy in several in vivo preclinical animal models. Debio 1347 is expected to become a tailored treatment which will be developed with a companion diagnostic. More info: http://bit.ly/2xHPMKb that could be safely administered was determined. This information was needed to start the second part of the trial described above.

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B.

Talk with your medical doctor

If you are interested in participating in an upcoming clinical trial, ask your doctor if a clinical trial might be right for you. Your doctor knows both you and your health history, which is invaluable in making this decision. Your doctor can help you gather the information needed to locate a trial and help you identify what questions might be important to ask before deciding to participate. When you join a clinical trial, you will still receive care from your primary doctor for your overall health. Most trials are only for a limited time and only pertain to the condition being studied.d.

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Find the trials on the map

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